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标题：Effect of Pulse on Iontophoretic Delivery of Desmopressin Acetate in Rats
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作者：Masashi NAKAKURA ; Yasuki KATO ; Eiji HAYAKAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：5
页码：738-740
DOI：10.1248/bpb.19.738
出版社：The Pharmaceutical Society of Japan
摘要：The effect of pulse parameters (duty and frequency) in a constant direct current iontophoresis on the antidiuretic response (elevation in rat urinary osmotic pressure) of desmopressin acetate (DDAVP) was examined in diabetes insipidus rats. Although antidiuretic response was not affected by frequency, it was induced by a duty of more than 26% and prolonged with increasing duty. A positively relationship between dose and AUC, the area under the osmotic pressure-time curve, was confirmed by intravenous administration of DDAVP, and the AUC induced by the iontophoretic delivery increased with increasing duty. The voltage across rat skin required to maintain a constant current density was investigated. A higher voltage was initially applied rat skin in a higher duty. This was related the prolonged pharmacological response induced by iontophoresis.
关键词：iontophoresis;desmopressin acetate;pulse current;skin premeability