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标题：Electrophoretic Patterns of Urinary Proteins of Diabetics in the Pre, Early and Overt Naphropathy Stages
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作者：Nobuo HIRATSUKA ; Kiyoko SHIBA ; Katsumi SHINOMURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：6
页码：651-655
DOI：10.1248/bpb.20.651
出版社：The Pharmaceutical Society of Japan
摘要：Urinary proteins of patients with diabetes mellitus (DM) were analyzed using cellulose acetate membrane electrophoresis, to determine the clinical usefulness of fraction patterns of the proteins in detecting the group at high risk for diabetic nephropathy.We divided the protein patterns into 5 groups. Four groups (I, II, III, IV) were found in the healthy group and a newly classified group was termed group 0 and was characterized by a prominent albumin peak with a negligible or small globulin peak.The incidence of groups, 0, I, II, III and IV, and 36.6%, 13.3%, 18.7%, 10.7% and 22.7%, respectively. This distribution was clearly different from that of healthy subjects and the most characteristic feature of diabetics was that group 0 accounted for 36.6% of the total cases.Characteristic features of each group were examined from the aspect of laboratory and clinical findings.Urinary protein patterns were concluded to be useful not only to predict the high risk group for diabetic nephropathy in the preclinical stage but also to discriminate nephropathic types of glomerular or tubular origin. It is useful for clinicians to know the risk stage and prognosis for diabetic nephropathy.
关键词：cellulose acetate membrane electrophoresis;urinary protein fraction;diabetic nephropathy;total protein;albumin;N-acetyl-β-D-glucosaminidase (NAG)