文章基本信息

标题：Anti Candida Activity of Induced Transferrin in Mice Immunized with Inactivated Candida albicans
本地全文：下载
作者：Toshihiko WATANABE ; Hironori TANAKA ; Noriko NAKAO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：6
页码：637-640
DOI：10.1248/bpb.20.637
出版社：The Pharmaceutical Society of Japan
摘要：Mice immunized with formalin-killed Candida albicans were resistant to challenge by a lethal amount of viable C. albicans. The growth-inhibitory activity to C. albicans was detected in sera from the immunized mice, and was inhibited by the addition of anti-transferrin antibody or ferric sulfate. Both the amount of transferrin and the unsaturated iron-binding capacity (UIBC) in the serum were significantly increased, indicating that apo-transferrin increased in the immunized mice. Moreover, the intraperitoneal administration of apo-transferrin enhanced the protection from the Candida infection in vivo.
关键词：Cndida albicans;apo-transferrin;unsaturated iron-binding capacity (UIBC);infection