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标题：RESPONSE DIFFERENCES AMONG MOUSE STRAINS IN DNA DAMAGE AND SKIN CARCINOGENICITY OF 7, 12-DIMETHYLBENZ[a]ANTHRACENE ARE DUE TO INDUCIBLE ARYL HYDROCARBON HYDROXYLASE ACTIVITY
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作者：Sei-ichi SATO ; Isao TOMITA
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：1
页码：90-92
DOI：10.1248/bpb.21.90
出版社：The Pharmaceutical Society of Japan
摘要：Strain differences of mice in the induction of DNA damage in peripheral blood cells and skin tumors were investigated using 7, 12-dimethylbenz[a]anthracene (DMBA). DMBA-induced DNA damage and skin tumorigenesis were evaluated using the single cell gel electrophoresis (SCGE) assay and 2-stage carcinogenicity study, respectively. DNA damaged cells were markedly increased in the aryl hydrocarbon hydroxylase (AHH)-inducible mice, BALB/c and C57BL/6, as compared with the AHH-noninducible mice, DBA/2, in the SCGE assay. The AHH-inducible mice were more sensitive to DMBA than the AHH-noninducible mice in the 2-stage carcinogenicity study. These results strongly suggest that the genetic capacity to metabolize PAH is associated with the mutagenecity and carcinogenecity of DMBA.
关键词：mouse strain difference;single cell gel electrophoresis assay;2-stage carcinogenesis;7, 12-dimethylbenz[a]anthracene