文章基本信息

标题：Induction of Apoptotic Cell Death in HL-60 Cells by Acteoside, A Phenylpropanoid Glycoside
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作者：Makoto INOUE ; Zentaro SAKUMA ; Yukio OGIHARA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：1
页码：81-83
DOI：10.1248/bpb.21.81
出版社：The Pharmaceutical Society of Japan
摘要：Acteoside, a phenylpropanoid glycoside with anti-oxidative activity, induced cell death in promyelocytic leukemia HL-60 cells with an IC₅₀ value of 26.7μM. Analysis of extracted DNA on agarose gel electrophoresis revealed that aceteoside induced the internucleosomal breakdown of chromatin DNA characteristic of apoptosis.Apoptosis-specific DNA fragmentation was clearly detectable 4h after treatment with acteoside and was indepedent of the cell cycle phase. These data indicate that acteoside induces apoptosis in HL-60 cells.
关键词：acteoside;apoptosis;HL-60;phenylpropanoid glycoside