文章基本信息

标题：Augmentation of Sinecomitant Immunity in Mice by γ-(9H-Purine-6-yl)thiomethyl L-Glutamate (6-MPG), a Water-Soluble Derivative of 6-Mercaptopurine
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作者：Tatsuo KASHIDA ; Naoko NARASAKI ; Kenji TSUJIHARA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：1
页码：16-21
DOI：10.1248/bpb.21.16
出版社：The Pharmaceutical Society of Japan
摘要：Effects of the administration of γ-(9H-purine-6-yl)thiomethyl L-glutamate (6-MPG), a water-soluble derivative of 6-mercaptopurine, on concomitant and sinecomitant immunity against the implanted MethA tumor were studied in BALB/c mice. In the concomitant immunity experiments, mice were intradermally inoculated with 1×10⁵MethA cells at the right inguinal region on day 0. In sinecomitant immunity experiments, mice were similarly inoculated on day -21, and the grown tumor was excised on day -11. Both the tumor-bearing and tumor-ectomized animals were re-inoculated with 3×10⁶MethA cells intradermally at the left inguinal region on day 10. Administration of 6-MPG (100mg/kg, i.p.) on days 3 through 7 significantly inhibited growth of the re-inoculated tumor in both series of experiments. Cyclophosphamide, adriamycin, mitomycin C and cis-diamminedichloroplatinum (II) had no significant effect on the growth of the re-inoculated tumor in the tumor-ectomized mice. Spleen cells harvested from the 6-MPG-treated tumor-ectomized mice showed a strong tumor-neutralizing activity (Winn assay).
关键词：6-mercaptopurine (6-MP);water-soluble-6-mercaptopurine derivative;concomitant immunity;sinecomitant immunity;tumor-ectomized mouse