文章基本信息

标题：Inhibitory Effects of Pentamethine Trinuclear Cyanine Dyes on ADP/Fe2+-Induced Lipid Peroxidation in Rat Liver Mitochondria : Changes in the Mode of Action with the Hydrophobic Nature of the Dyes
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作者：Kentaro KOGURE ; Hironori SASSA ; Kazutoyo ABE 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：2
页码：180-183
DOI：10.1248/bpb.21.180
出版社：The Pharmaceutical Society of Japan
摘要：The effects of various pentamethine trinuclear cyanine dyes, each of which has three alkyl chains, on ADP/Fe²⁺-induced lipid peroxidation in rat liver mitochondria were examined. Although the dye having the shortest -C₂H₅ chains (tri-S-C₂(5)) did not show any appreciable effect, the dyes having -C₄H₉ (tri-S-C₄(5)), -C₇H₁₅ (tri-S-C₇(5)), and -C₁₂H<25> (tri-S-C₁₂(5)) chains significantly inhibited lipid peroxidation, the most potent inhibitory effect being observed with tri-S-C₇(5). The mode of antiperoxidation effect of the dyes was dependent on the length of the alkyl chains. The relatively hydrophilic dye tri-S-C₄(5) was suggested to scavenge radicals more efficiently at or near the membrane surface rather than in the interior of the lipid membrane, whereas the more hydrophobic dye tri-S-C₇(5) was suggested to scavenge radicals efficiently in the membrane rather than at or near the membrane surface. The hydrophilic/hydrophobic balance of the dye was found to regulate the site of action of the dyes.
关键词：cyanine dye;antioxidant;ADP/Fe2+-induced lipid peroxidation;mitochondria;hydrophobicity