文章基本信息

标题：Screening of an Inhibitor of the Tetracycline Efflux Pump is a Tetracycline-Resistant Clinical-Isolate of Staphylococcus aureus 743
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作者：Takahiro HIRATA ; Rumi WAKATABE ; Joergen NIELSEN 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：7
页码：678-681
DOI：10.1248/bpb.21.678
出版社：The Pharmaceutical Society of Japan
摘要：Clinically-isolated methicillin-resistant Staphylococcus aureus (MRSA) strain 743 exhibited resistance to tetracycline as judged from the active efflux of the drug. The efflux of tetracycline was inhibited by an uncoupler, carbonyl cyanide m-chlorophenylhydrazone (CCCP), and minocycline. Inhibitors of the efflux pump were examined in this strain to determine the cellular accumulation of tetracycline. Out of seven compounds examined, three caused a significant increase in the cellular concentration of tetracycline by inhibiting the efflux pump. Two of them seem to be energy inhibitors. Ro 07-3149 inhibited the efflux pump without affecting the energy state, and exhibited very low antibacterial activity but showed weak synergy with tetracycline.
关键词：S. aureus;tetracycline;drug resistance;inhibitor;drug efflux