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标题：High Absorbency and Subchronic Morphologic Effects on the Nasal Epithelium of a Nasal Insulin Powder Dosage Form with a Soybean-derived Sterylglucoside Mixture in Rabbits
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作者：Tomonaga YAMAMOTO ; Yoshie MAITANI ; Taeko ANDO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：8
页码：866-870
DOI：10.1248/bpb.21.866
出版社：The Pharmaceutical Society of Japan
摘要：A soybean-derived steryglucoside mixture (SG) is a potential enhancer of the nasal absorption of insulin.The aim of the study was to examine the absorption of insulin given as the powder dosage form with SG and excipient and to determine the subchronic effects of SG on the morphology of rabbit nasal epithelium. The insulin powder dosage form with SG was administered to the rabbit nasal cavity for five successive days. The average bioavailability and the average pharmacological bioavailability of insulin were about 25.0 and 61.6% respectively. The nasal mucosa was taken from the nasal cavity and side-effects were investigated using an optiphoto light microscope. The insulin powder dosage form with SG produced no signs of inflammation, erosion or squamous metaplasia. These findings indicate that SG can be considered as a safe and effective enhancer and excipient in the nasal insulin powder dosage form.
关键词：insulin;nasal administration;sterylglucoside;powder dosage form;morphologic examination