文章基本信息

标题：Development of a Computer Program, MDGP, for Population Pharmacokinetic Analysis Written Using ANSI C Language on Wide Platforms
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作者：Koji TANIKAWA ; Yoshiaki MATSUMOTO ; Mitsuo MATSUMOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：8
页码：847-852
DOI：10.1248/bpb.21.847
出版社：The Pharmaceutical Society of Japan
摘要：MDGP, a computer program for population pharmacokinetics, has been developed. This program is based on maximum likelihood estimation with poly-dimensional normal distribution errors, and variable metric methods, direction set methods, conjugate gradient methods and the polytope method are provided as minimizations of objective function. The source codes of MDGP are described using ANSI C language. MDGP is able to run on wide platforms equipped with an ANSI C compiler. Users can use algebraic, ordinary differential and Laplace-transformed equations as descriptions of a pharmacokinetic model. Partial differential equations for each model parameter are not needed. Comparison of the estimated parameters, the iteration counts until convergence and objective function value, using MDGP and NONMEM, revealed that the calculation performance of the two programs are comparable.The MDGP is through to be useful for the analysis of various pharmacokinetic models, including population pharmacokinetic analysis.
关键词：population pharmacokinetic analysis;MDGP;NONMEM;C language;maximum likelihood estimation;ordinary differential equation