文章基本信息

标题：Polulation Pharmacokinetic Analysis of Mexiletine in Adult Arrhythmic Patients in Japanese Population
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作者：Kazunori UENAKA ; Toshiko KOUE ; Tetsushi IWAI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：8
页码：844-846
DOI：10.1248/bpb.21.844
出版社：The Pharmaceutical Society of Japan
摘要：We analyzed mexiletine in Japanese patients using populaiton pharmacokinetics. 139 serum concentration data, which were collected for therapeutic drug monitoring from 121 patients, were used for this analysis. We also investigated influence of age and gender on pharmacokinetics, and age was found to be an influential factor on clearance. The final pharmacokinetic parameters are, CL/F=0.580-0.00369·AGE (l/h/kg) and V_d/F=6.63 (L/kg). These results shoulds be useful for adjusting the dosage to a patient's age for the prevention of an adverse reaction caused by overexposure.
关键词：mexiletine;population pharmacokinetics;age;Japanese patient