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标题：Anti-HIV-1 Activity of Herbs in Labiatae
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作者：Katsuhiro YAMASAKI ; Masami NAKANO ; Takuya KAWAHATA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：8
页码：829-833
DOI：10.1248/bpb.21.829
出版社：The Pharmaceutical Society of Japan
摘要：The anti-HIV-1 activity of aromatic herbs in Labiatae was evaluated in vitro. Forty five extract from among 51 samples obtained from 46 herb species showed significant inhibitory effects against HIV-1 induced cytopathogenicity in MT-4 cells. In particular, the aqueous extracts of Melissa officinalis, a family of Mentha×piperita "grapefruit mint", Mentha×piperita var. crispa, Ocimum basilicum cv "cinnamon", Perilla frutescens var. crispa f.viridis, Prunella vulgaris subsp. asiatica and Satureja montana showed potent anti-HIV-1 activity (with an ED of 16μg/ml). The active components in the extract samples were found to be water-solubel polar substances, not nonpolar compounds such as essential oils. In addition, these aqueous extracts inhibited giant cell formation in co-culture of Molt-4 cels with and without HIV-1 infection and showed inhibitory activity against HIV-1 reverse transcriptase.
关键词：HIV-1;antiviral activity;Labiatae;Melissa officinalis;Ocimum basilicum cv "cinnamon";Perilla frutescens var. crispa f. viridis