文章基本信息

标题：β-Glucuronidase-Inhibitory Activity and Hepatoprotective Effect of Ganoderma lucidum
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作者：Dong-Hyun KIM ; Sang-Bum SHIM ; Nam-Jae KIM 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：2
页码：162-164
DOI：10.1248/bpb.22.162
出版社：The Pharmaceutical Society of Japan
摘要：To prove the relationship between the fluctuation in serum β-glucuronidase level and hepatotoxicity, an inhibitor of β-glucuronidase from G. lucidum was isolated and its hepatoprotective activity was investigated. The ether fraction of G. lucidum, which had potent β-glucuronidase-inhibitory activity, protected against CCl₄-induced liver injury. From this ether fraction, ganoderenic acid A, was isolated as the potent inhibitor of β-glucuronidase. It had a potent hepatoprotective effect against CCl₄-induced liver injury. These results suggest that the β-glucuronidase seems to be closely related to liver injury, which could be prevented by β-glucuronidase inhibitors.
关键词：β-glucuronidase;G. lucidum;ganoderenic acid A;hepatoprotective;hepatotoxicity