文章基本信息

标题：Chemotherapy with Hybrid Liposomes for Melanomatosis
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作者：Akihiro KANNO ; Kenji TSUZAKI ; Makoto MIYAGI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：9
页码：1013-1014
DOI：10.1248/bpb.22.1013
出版社：The Pharmaceutical Society of Japan
摘要：The inhibitory effects of the hybrid liposomes on the growth of B-16 melanoma cells in vitro and in vivo were examined. The 50% inhibitory concentration of the hybrid liposomes composed of 90 mol% dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylenedodecyl ether (C₁₂(EO)₁₀) was one-twelfth of that of DMPC liposomes. It was noteworthy that for the first time significantly prolonged survival was obtained using a mouce model of carcinoma after the administration of the hybrid liposomes of 90 mol% DMPC/10 mol% C₁₂(EO)_n (n=10 or 23) without antitumor drugs.
关键词：liposome;chemotherapy;antitumor;melanoma