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标题：Effects of Dai-kenchu-to on Levels of 5-Hydroxytryptamine (Serotonin) and Vasoactive Intestinal Peptides in Human Plasma
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作者：Toshiaki NAGANO ; Hiroki ITOH ; Masaharu TAKEYAMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：3
页码：352-353
DOI：10.1248/bpb.23.352
出版社：The Pharmaceutical Society of Japan
摘要：We examined the effects of Dai-kenchu-to (DKCT) on the levels of vasoactive intestinal peptide (VIP) and 5-hydroxytryptamine (serotonin; 5-HT) in plasma taken from 6 healthy subjects. A single oral administration of 7.5 g DKCT caused significant increases in plasma VIP at 30, 60 to 90 and 120 min (3.5-5.5 pg/ml), compared with the response in a placebo group (about 1.0 pg/ml). DKCT also caused significant increases in plasma 5-HT at 30 (121.8±7.3 ng/ml) and 60 (156.5±8.0 ng/ml) min, compared with the response in the placebo group (about 101 ng/ml). These results indicate that the stimulatory effect of DKCT on VIP-immunoreactive substance (VIP-IS) secretion is due, at least in part, to increased 5-HT levels in the abdomen. As a consequence, increased VIP-IS may improve feelings of coldness in the abdomen.
关键词：Dai-kenchu-to;Kampo;vasoactive;intestinal peptide;5-hydroxytryptamine;neuropeptide