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标题：The Hypoglycemic Effect of (7R*, 9aS*)-7-Phenyl-octahydroquinolizin-2-one in Mice
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作者：Hajime KUBO ; Junji KOBAYASHI ; Kimio HIGASHIYAMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：9
页码：1114-1117
DOI：10.1248/bpb.23.1114
出版社：The Pharmaceutical Society of Japan
摘要：(-)-Multiflorine (1), which was isolated from leguminous plants, produced a hypoglycemic effect when administered to mice with streptozotocin-induced diabetes. (-)-Multiflorine has an enaminone type conjugation on the A-ring, which is unusual in lupine alkaloids. Proceeding on the assumption that the A-B ring is responsible for the activity, several compounds bearing quinolizidin-2-one were synthesized and their hypoglycemic effects were examined. The hypoglycemic effect of (7R^*, 9aS^*)-7-phenyl-octahydroquinolizin-2-one was approximately 4 times stronger than that of (-)-multiflorine measured by oral glucose tolerance test in normal mice. This result indicates that compounds possessing the quinolizidin-2-one ring system as the basic structure may be possible lead compounds for a new type of diabetes drug.
关键词：quinolizin-2-one;multiflorine;hypoglycemic effect;lupine alkaloid