文章基本信息

标题：Enhancement of O2-Production from Resident Peritoneal Macrophages by Low-Dose in Vivo γ-Irradiation
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作者：Yuko IBUKI ; Rensuke GOTO
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：9
页码：1094-1096
DOI：10.1248/bpb.23.1094
出版社：The Pharmaceutical Society of Japan
摘要：Superoxide anion (O₂^-) production after very low-dose in vivo irradiation (4cGy) was examined in resident peritoneal macrophages. The level of production rapidly increased following treatment with the PKC activator, phorbol 12-myristate 13-acetate (PMA), but no further enhancement by low-dose in vivo irradiation was observed. On the other hand, treatment with zymosan A gradually induced O₂^- production, which was further increased in low-dose in vivo irradiated macrophages. The amounts of phagocytosis of zymosan A were not changed by in vivo irradiation. This indicated that the enhancement of O₂^- production was not due to an increase in phagocytotic activity by low-dose in vivo irradiation. Our results show that low-dose in vivo irradiation induces production of reactive oxygen species by macrophages, not only nitric oxide as reported in our previous paper but also O₂^-. This may contribute to the increase of cytolytic activity of macrophages after low-dose in vivo irradiation.
关键词：superoxide;macrophage;irradiation;low-dose