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标题：Diversity and Substrate Specificity in the Structures of Steroidogenic Cytochrome P450 Enzymes
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作者：Hiroshi Sugimoto ; Yoshitsugu Shiro
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2012
卷号：35
期号：6
页码：818-823
DOI：10.1248/bpb.35.818
出版社：The Pharmaceutical Society of Japan
摘要：Mammalian cytochrome P450 (CYP) comprise a large group of enzymes that play many important roles in the biosynthesis of steroid hormones and vitamins. In addition, they participate in the metabolism of drugs and xenobiotics. All known mammalian CYP enzymes are membrane-associated proteins, which complicated their X-ray crystallographic analysis. In recent years, however, significant progress has been made in the X-ray crystallographic analysis of mammalian CYP enzymes involved in the steroid hormone and vitamin D₃ metabolism. The knowledge from three-dimensional structures of mammalian CYP enzymes will benefit drug discovery and development.
关键词：cytochrome P450;X-ray crystallography;steroid;vitamin