文章基本信息

标题：Pharmacological and Pharmaceutical Properties of Freeze-Dried Formulations of Egg Albumin, Indomethacin, Olive Oil, or Fatty Acids
本地全文：下载
作者：Yasuhiro TSUJI ; Hisao KAKEGAWA ; Hideki MIYATAKA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：7
页码：675-678
DOI：10.1248/bpb.16.675
出版社：The Pharmaceutical Society of Japan
摘要：Formulations consisting of egg albumin, indomethacin (IND), and olive oil or fatty acids, were prepared by vigorous stirring using a high-speed homogenizer and subsequent freeze-drying. To confirm the anti-inflammatory properties and ulcerogenic effects of the formulatios, we examined the action of the formulations on carrageenan-induced edema in rats as well as their ulcerogenic actions in the same species. Compared with IND alone, albumin-IND-olive oil (9 : 1 : 4.3), albumin-IND-linolenic acid (9 : 1 : 4.3), albumin-IND-liolic acid (9 : 1 : 4.3), albumin-IND-oleic acid (9 : 1 : 4.3), albumin-IND-stearic acid (9 : 1 : 4.3), and albumin-IND-tristearin (9 : 1 : 4.3) formulations all exhibited a more potent inhibitory effect on carrageenan-induced edema. In addition, the inhibitory effects on edema formation of an albumin-IND (9 : 1) complex was as strong as that of IND alone. These results suggested that the biovailability of IND was increased by olive oil, fatty acid, and tristearin as absorbefacient agent. The increase in the bioavailability was evident from the fact that the mean plasma levels, maximum plasma levels (C_max), and area under plasma concentration-time curve (AUC) values after oral administration of the albumin-IND-olive oil (9 : 1 : 4.3) formulation was significantly greater than that after administration of the drug alone. With respect to their ulcerogenic properties, the formulations were significantly less active than IND alone, suggesting that a reduction in the ulcerogenic activity of IND was by produced complexation with egg albumin.
关键词：egg albumin;olive oil;indomethacin;bioavailability;anti-inflammatory action;ulcerogenicity