文章基本信息

标题：Effect of β-Alanyl-L-Histidinato Zinc on Bone Metabolism in Rats with Adjuvant Arthritis
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作者：Yoshihide SEGAWA ; Naoki TSUZUIKE ; Yoshihiko ITOKAZU 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1993
卷号：16
期号：7
页码：656-659
DOI：10.1248/bpb.16.656
出版社：The Pharmaceutical Society of Japan
摘要：The effect of a new zinc compound, β-ananyl-L-histidinato zinc (AHZ), on osteopenia was investigated in rats with adjuvant arthritis. Arthritis was induced in female rats by administering 1% Mycobaterium butyricum (MB) into the subplantar surface of the right hind paw. AHZ (10, 30 and 100 mg/kg body weight) was orally administered to MB-treated rats 28 times at 24-h intervals, and the rats were bled 24 h after the last administration. Treatment with MB caused a ramrkable increase in paw volume and a corresponding decrease in the ratio of albumin per globulin in serum, indicating taht the treatment induces inflammation. These alteration swere not significantly changed by the administration of AHZ (10, 30 and 100 mg/kg). Serum calcium and zinc concentrations are significantly decreased in rats with adjuvant arthritis. These decreases were completely restored by the administration of AHZ (30 and 100 mg/kg). Furthermore, the inflammation-induced decreases in alkaline phosphatase activity and calcium content in the femoral diaphysis were clearly blocked by the administration of AHZ (30 and 100 mg/kg). Also, the larger doses of AHZ (30 and 100 mg/kg) produced a significant increase in femoral-diaphyseal deoxyribonucleic acid and in the zinc content in rats with adjuvant arthritis. These results suggest that AHZ has a stimulating effect on bone formation in the femoral diaphysis of rats with adjuvant arthritis, although the compound did not have an anti-arthritic effect.
关键词：β-alanyl-L-histidinato zinc;bone metabolism;inflammation;osteopenia;rat femur