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标题：Inter-organ Relation between Salivary Gland and Kidney in Lithium Excretion. IV. Saturation of Inhibitory Effect of NaCl on Ductal Reabsorption of Li+ in Beagle Dogs
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作者：Junya HIGUCHI ; Jun WATANABE ; Yayoi HAYASHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：2
页码：356-358
DOI：10.1248/bpb.17.356
出版社：The Pharmaceutical Society of Japan
摘要：The inhibitory effect of NaCl coadministration on the reabsorption of Li⁺ in the salivary ducts and the renal tubules was investigated in beagle dogs. Following the bolus intravenous administration of LiCl (0.145 meq/kg), 50 ml of NaCl solution (100, 200 meq/l) was administered orally each hour, and parotid saliva (Pr) and mandibular-sublingual saliva (MS) were collected under the continuous stimulation of salivation with citric acid. The renal clearance of Li⁺ increased with the increased concentration of administered NaCl solution. This could be a result of the competitive inhibition of the tubular reabsorption of Li⁺ by Na⁺. The salivary clearance of Li⁺ also tended to increase by the administration of NaCl. These results suggest the existence of a reabsorption process of Li⁺ in the salivary glands similar to that in the renal tubule. However, when the administered NaCl was increased from 100 to 200 meq/l, the renal clearance was further increased, but the salivary clearance was not. This suggests that the transport capacity of Li⁺ reabsorption is relatively small in the salivary glands, compared with that in the renal tubule, and that the inhibitory effect of NaCl on Li⁺ reabsorption had already reached a maximum level when 100 meq/l NaCl was administered.
关键词：lithium;sodium;sodium chloride coadministration;salivary clearance;renal clearance;dog