文章基本信息

标题：Analysis of the Transport of Valproic Acid into Saliva from Serum
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作者：Yoshinari SUZUKI ; Toshihiko UEMATSU ; Atsuhiro MIZUNO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：2
页码：340-344
DOI：10.1248/bpb.17.340
出版社：The Pharmaceutical Society of Japan
摘要：A study was conducted to explore whether a positive correlation between serum and salivary concentrations of the well-known antiepileptic drug, valproic acid (VPA), in epileptic patients could be explained by facilitated diffusion. The total concentration in saliva (C_s) would be related to the apparent ratio (R_app=100·C_s/C_t) of C_s to the total concentration in serum (C_t) as follows : C_s=A·R_app+B. This equation can be illustrated with microcomputer-simulated figures by assuming a process of facilitated diffusion for the transport of VPA into saliva from blood by the mechanism of monocarboxylic acid absorption through the intestinal brush-border membrane vesicles. The above equation has been proved to be valid when applied to the data reported separately by Gugler and coworkers and by Nitsche and Mascher, who evaluated the pharmacokinetics of VPA. Moreover, we can estimate the serum concentration with the salivary concentration using the above equation.
关键词：valproic acid;saliva;serum;TDM;transport