文章基本信息

标题：Inhibition of Carbon Tetrachloride-Induced Hepatotoxicity by Neopterins
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作者：Takeshi ICHO ; Shuji KOJIMA ; Kazumori YOSHIKAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：7
页码：914-916
DOI：10.1248/bpb.17.914
出版社：The Pharmaceutical Society of Japan
摘要：We investigated the inhibitory effects of neopterin (NP) and its reduced form, 5, 6, 7, 8-tetrahydroneopterin (NPH4), on carbon tetrachloride (CCl₄)-induced hepatotoxicity. In in vivo experiments, intraperitoneal administration of NP or NPH4 significantly inhibited the elevation of plasma alanine aminotransferase activity induced by CCl₄ in mice. In in vitro experiments using cultured rat hepatocytes, CCl₄ induced in a manner which was both time- and dose-dependent lactate dehydrogenase release, and the addition of NP or NPH4 to the culture-medium significantly inhibited its release from cells. NPH4, but not NP, reacted directly with a stable radical, 1, 1-diphenyl-2-picrylhydrazyl. These results suggest that NP and NPH4 inhibit CCl₄-induced hepatotoxicity through different mechanisms.
关键词：neopterin;carbon tetrachloride;hepatotoxicity;free radical