文章基本信息

标题：Enhanced Cholesterol Esterase Activity in the Pancreas of Rats with Streptozotocin-Induced Diabetes
本地全文：下载
作者：Genichiro OSHIMA ; Yasuhito NAKAGAWA
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：7
页码：894-897
DOI：10.1248/bpb.17.894
出版社：The Pharmaceutical Society of Japan
摘要：Diabetes was induced in rats by the intravenous administration of streptozotocin (STZ; 60 mg/ml). The activity of cholesterol esterase (CEase) in various tissues was determined by use of either a fluorogenic or radioactive substrate. Significant CEase activity was detected in extracts of pancreas. The specific activity of pancreatic CEase was considerably greater in pancreatic extracts from diabetic rats compared with normal rats. The activity of pancreatic CEase increased 6 d after the injection of STZ, but the difference was not statistically significant. It reached a maximum value approximately twice that of normal pancreas at 30 d with statistic significance. The highest specific activity of pancreatic CEase was found in the cytosolic fraction from diabetic rats, whereas the specific activity of the enzyme was lowest the same fraction from normal rats.
关键词：cholesterol esterase;pancreas;streptozotocin;absorption;hypercholesterolemia;hyperphagia