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标题：Anti-inflammatory Effect of 22-Oxa-1α, 25-dihydroxyvitamin D3 on Carrageenin-Induced Inflammation in Rats
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作者：Michinori HIRATA ; Hideko KATO ; Hayami DEBUCHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：8
页码：1130-1131
DOI：10.1248/bpb.17.1130
出版社：The Pharmaceutical Society of Japan
摘要：The anti-inflammatory effect of 22-oxa-1α, 25-dihydroxyvitamin D₃ [22-oxa-1α, 25 (OH)₂D₃], an analogue of the active form of vitamin D₃, was studied regarding carrageenin-induced inflammation in rats. In the early phase of the inflammation, the formation of granulation tissue and the weight of exudate were significantly suppressed by both oral and local administrations of 22-oxa-1α, 25 (OH)₂D₃ daily for 4d (day 0-3) after carrageenin injection, though the local injection of 22-oxa-1α, 25 (OH)₂D₃ (7 and 10μg/kg). Similarly, oral and local administrations of 22-oxa-1α, 25 (OH)₂D₃ from day 4 to 7 significantly suppressed the increase in exudate and the proliferation of granulation tissue in the late phase of carrageenin-induced inflammation in rats. The results suggest that 22-oxa-1α, 25 (OH)₂D₃ has an anti-inflammatory activity on both the acute and proliferative phases of inflammation in rats.
关键词：22-oxa-1α, 25-dihydroxyvitamin D3;inflammation;anti-inflammatory agent;granulation tissue;exudate