文章基本信息

标题：Suppressive Effects of the Anti-allergic Drugs, Tranilast and Azelastine, on the Lysophosphatidylserine-Dependent Activation of Rat Mast Cells
本地全文：下载
作者：Kiyoto HARA ; Hidetada KOMATSU ; Naoyuki TSUTSUMI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1994
卷号：17
期号：8
出版社：The Pharmaceutical Society of Japan
摘要：Anti-allergic drugs, tranilast and azelastine, were examined for their effects on lysophosphatidylserine (lysoPS)-dependent histamine release from rat mast cells. Although both compounds suppressed the histamine release in a dose-dependent manner, the inhibition was affected by lysoPS concentration differently. In the presence of an increasing concentration of lysoPS, the suppressive effect of tranilast decreased. The inhibition by azelastine, however, was independent of the concentration of lysoPS. The findings suggest that these two drugs inhibit lysoPS-dependent histamine release through essentially different routes.