文章基本信息

标题：Study on Hepatic Artery Chemoembolization Using Temperature-Sensitive Liposome or Lipiodol Emulsion
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作者：Atsuo ONO ; Isamu HORIKOSHI ; Masaharu UENO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：2
页码：279-283
DOI：10.1248/bpb.18.279
出版社：The Pharmaceutical Society of Japan
摘要：As a novel method for the medical application of liposomes, we have tried hepatic artery chemoembolization using temperature-sensitive liposomes with hyperthermia for the treatment of hepatic tumors. In this study, the effect of temperature-sensitive liposomes was compared with that of Lipiodol emulsion, which has been used clinically. The temperature-sensitive liposomes, consisting of dipalmitoylphosphatidylcholine or Lipiodol emulsions entrapping doxorubicin, were administered into the hepatic artery of hepatic tumor-bearing rats via a cannula. Doxorubicin administered in a liposomal form showed a high accumulative property toward tumors, with heating, while that in the emulsion form showed a show release property toward tumors. Not noly was tumor growth inhibited, but also, an actual diminishing of the tumor was observed in each form. Side effects were also examined : an abnormal rise in GPT, or necrosis of the normal tissues in liver, which was often observed in hepatic artery chemoembolization using Lipiodol emulsion, was remarkably reduced in the liposomal chemoembolization.
关键词：temperature-sensitive liposome;Lipiodol emulsion;therapeutic effect;side effect;reverse phase evaporated vesicle;doxorubicin