文章基本信息

标题：Interactions between Bacteriohopane-32, 33, 34, 35-tetrol and Liposomal Membranes Composed of Dipalmitoylphosphatidylcholine
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作者：Zhansong CHEN ; Yukio SATO ; Izo NAKAZAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：3
页码：477-480
DOI：10.1248/bpb.18.477
出版社：The Pharmaceutical Society of Japan
摘要：The effects of bacteriohopane-32, 33, 34, 35-tetrol (Tetrol), on liposomal membranes composed of dipalmitoyl-phosphatidylcholine (DPPC) were examined and compared with those of bacteriohopane-32-ol (Monol) and cholesterol (Chol) by means of ESR and NMR techniques. ¹H-NMR spectra of Tetrol-incorporated DPPC membranes showed splitting of the signals of the choline N-methyl resonance, whereas Monol-and Chol-incorporated membranes showed no splitting of signals above the transition temperature of DPPC. It was suggested that the incorporation of Tetrol affected only the fluidity near the polar head groups of the DPPC membranes. The characteristics of the interactions between Tetrol and membranes are due to the fact that in DPPC bilayers Tetrol and Monol have an inverted orientation contrary to Chol, and that the hydroxy groups of Tetrol suppress the hydrophobic interaction between DPPC molecules whereas the methyl groups of the hopanoid ring promote this.
关键词：hopanoid;cholesterol;membrane fluidity;ESR spectrum;NMR spectrum