文章基本信息

标题：Suppressive Effect of Molybdenum on Hepatotoxicity of N-Nitrosodiethylamine in Rats
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作者：Toshiaki KOIZUMI ; Kenichi TAJIMA ; Nobuo EMI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：3
页码：460-462
DOI：10.1248/bpb.18.460
出版社：The Pharmaceutical Society of Japan
摘要：In order to elucidate the mechanism by which molybdenum prevents the carcinogenesis of N-nitroso compounds, the effects of Na₂MoO₄-pretreatment on N-nitrosodiethylamine (NDEA)-induced DNA strand breaks, fluctuation in cation contents and lipid peroxidation levels in rat liver were examined. Male Wistar rats weighing 170-190g were pretreated with Na₂MoO₄ (1.24 mmol/kg body weight, i.p., once a day) for 3 d and on day 4, they were exposed to NDEA (50 mg/kg body weight, once, i.p.). Three days after exposure to NDEA, the nitroso compound caused DNA strand breaks and disrupted potassium (K) and calcium (Ca) metabolism in the liver but did not affect lipid peroxidation levels. Na₂MoO₄-pretreatment prevented both NDEA-induced DNA damage and disruption of the metabolism of those cations but rather enhanced lipid peroxidation. These results suggest that Mo prevented NDEA-induced DNA damage by preventing disruption of intracellular Ca metabolism while stimulating the metabolism of the nitroso compound via a nontoxic pathway.
关键词：N-nitrosodiethylamine;DNA damage;lipid peroxidation;molybdenum;calcium-dependent endonuclease