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标题：Studies on Constituents with Cytotoxic and Cytostatic Activity of Two Turkish Medicinal Plants Phlomis armeniaca and Scutellaria salviifolia
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作者：Iclal SARACOGLU ; Makoto INOUE ; Ihsan CALIS 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1995
卷号：18
期号：10
页码：1396-1400
DOI：10.1248/bpb.18.1396
出版社：The Pharmaceutical Society of Japan
摘要：Ten known glycosidic compounds, betulalbuside A (1), 8-hydroxylinaloyl, 3-O-β-D-glucopyranoside (2) (monoterpen glycosides), ipolamiide (3) (iridoid glycoside), acteoside (verbascoside) (4), leucosceptoside A (5), martynoside (6), forsythoside B (7), phlinoside B (8), phlinoside C (9), and teucrioside (10) (phenylpropanoid glycosides) were isolated from methanolic extracts of Phlomis armeniaca and Scutellaria salviifolia (Labiatae). Structure elucidations were carried out using ¹H-, ¹³C-NMR and FAB-MS spectra, as well as chemical evidence. The cytotoxic and cytostatic activities of isolated compounds were investigated by the 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) method. Among the glycosides obtained here, caffeic acid-containing phenylpropanoid (or phenethyl alcohol, or phenylethanoid) glycosides were found to show activity against several kinds of cancer cells. However, they didn't affect the growth and viability of primary-cultured rat hepatocytes. Study of the structure-activity relationship indicated that ortho-dihydroxy aromatic systems of phenylpropanoid glycosides are necessary for their cytotoxic and cytostatic activities.
关键词：Phlomis armeniaca;Scutellaria salviifolia;Labiatae;phenylpropanoid glycoside;cytotoxic activity;cytostatic activity