文章基本信息

标题：Mechanism of Bradykinin-Induced Histamine Release from Rat Peritoneal Mast Cells
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作者：QiuE ZHAO ; Takuma MIHARA ; Yukio SUGIMOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：2
页码：237-240
DOI：10.1248/bpb.19.237
出版社：The Pharmaceutical Society of Japan
摘要：Bradykinin at concentrations higher than 2μM caused a significant histamine release from rat peritoneal mast cells when extracellular Ca²⁺ was removed from the medium. Under the same experimental conditions, bradykinin increased Ca²⁺ release from the intracellular Ca store of the rat peritoneal mast cells, and a clear relationship was observed between the magnitude of histamine release and an increase in fluorescence intensity. Addition of Ca²⁺ to the medium resulted in an inhibition of the response to bradykinin in a concentration-dependent manner. Almost the same results were obtained when Mg²⁺, Ba²⁺ and La³⁺ were added to the medium. Neither B₁ nor B₂ antagonists caused significant antagonistic effects on histamine release induced by bradykinin. However, B₂ antagonists caused a histamine release of the same potency as bradykinin when applied alone. These results indicate that bradykinin-induced histamine release is not attributable to a bradykinin receptor.
关键词：bradykinin;histamine release;intracellular Ca2+ release;mast cell