文章基本信息

标题：Lysophosphatidylserine Enhances Exogenous Type II Phospholipase A2-Induced Activation of Rat Serosal Mast Cells
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作者：Noriko HARA ; Makoto MURAKAMI ; Keizo INOUE 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：3
页码：474-476
DOI：10.1248/bpb.19.474
出版社：The Pharmaceutical Society of Japan
摘要：We have previously shown that exogenous type II phospholipase A₂ (PLA₂) alone elicits degranulation of mast cells, including rat serosal mast cells (SMC) and mouse bone marrow-derived mast cells (BMMC). Here we report that lysophosphatidylserine (lysoPS), a co-factor for activation of rodent SMC in response to some tyrosine kinase-coupled agonists, enhanced type II PLA₂-elicited histamine release from rat SMC. In contrast, mouse BMMC was insensitive to lysoPS. Our findings demonstrate a novel route for activation of SMC in that type II PLA₂ can act as a direct activator of SMC with enhancement by lysoPS, which is generated from membrane phosphatidylserine possibly by the action of the same enzyme.
关键词：type II phospholipase A2;lysophosphatidylserine;mast cell;degranulation