文章基本信息

标题：Comparative Pharmacodynamics of Eight Calcium Channel Blocking Agents in Japanese Essential Hypertensive Patients
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作者：Shuji SHIMADA ; Yukiko NAKAJIMA ; Koujirou YAMAMOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1996
卷号：19
期号：3
页码：430-437
DOI：10.1248/bpb.19.430
出版社：The Pharmaceutical Society of Japan
摘要：The relationships between plasma drug concentration and antihypertensive effect of eight calcium channel antagonists (nicardipine, nifedipine, nilvadipine, benidipine, manidipine, barnidipine, nitrendipine and efonidipine) in Japanese essential hypertensive patients were analyzed. Based on the effect compartment model, we could explain the long duration of the pharmacological effect, and there was significant correlation (r=0.876, p<0.05) between estimated EC₅₀ values and the dissociation constants (K_d) obtained from in vitro binding studies. We also developed the ion-channel binding model to understand the pharmacodynamics of long acting calcium antagonists. The model was also well fitted to antihypertensive effect data. A significant correlation between the apparent in vivo dissociation constants and in vitro K_d values was observed with a slope of 1.45 (r=0.913), suggesting that the mechanism of long-lasting antihypertensive effect of newer developed calcium antagonists is due to their high binding affinity at ion-channel sites.
关键词：calcium antagonist;antihypertensive effect;ion-channel binding;pharmacodynamic model