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标题：Anti-tumor Promoting Activities of Isoflavonoids from Wistaria brachybotrys
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作者：Takao KONOSHIMA ; Midori TAKASAKI ; Mutsuo KOZUKA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：8
页码：865-868
DOI：10.1248/bpb.20.865
出版社：The Pharmaceutical Society of Japan
摘要：Eight minor isoflavonoids (3-10) isolated from the knot of Wistaria brachybotrys were tested for their inhibitory effects on Epstein-Barr virus (EBV) activation induced by the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA), in Raji cells as a primary screening test for anti-tumor-promoters (cancer chemopreventive agents), and all the tested compounds showed inhibitory activity. Of these compounds, pendulone (3) was further examined on the cell cycle of Raji cells, and indicated strong inhibition on the effect of the cell cycle induced by TPA. In addition, the compound showed potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test of mouse skin using 7, 12-dimethylbenz[a]-anthracene and TPA. Consequently, it suggests that 3 could be a valuable chemopreventive agent in chemical carcinogenesis.
关键词：pendulone;Wistaria brachybotrys;anti-tumor-promoter;Epstein-Barr virus;cell cycle;two-stage carcinogenesis