文章基本信息

标题：Comparison of Characterization among Bordetella Calmodulin-Like Protein, Bovine Brain Calmodulin and Escherichia coli Acyl-Carrier Protein
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作者：Masaaki NAGAI ; Mineo WATANABE ; Masahiko ENDOH 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：9
页码：1036-1038
DOI：10.1248/bpb.20.1036
出版社：The Pharmaceutical Society of Japan
摘要：We previously reported that Bordetella calmodulin-like protein (CLP), like bovine brain calmodulin (CaM), enhances adenylate cyclase and phosphodiesterase activities. In this communication, antigenic and biochemical characters were compared between CLP and CaM. It was found that anti-CLP and anti-CaM sera obtained reacted with CaM and CLP, respectively. The amino acid composition of CLP was similar to CaM. The similarity was also found in an Escherichia coli acyl-carrier protein (ACP), a CA²⁺-binding protein. Though the amino acid sequence of N-terminus region of CLP has no significant homology with CaM, ACP has highly homology in its N-terminus similar to CaM. These results suggest that CLP might act as a Ca²⁺-binding protein, and/or an ACP during the activation of adenylate cyclase and phosphodiesterase.
关键词：Bordetella;calmodulin;calmodulin-like protein;acyl-carrier protein