文章基本信息

标题：Immunosuppressive Effects of Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity
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作者：Shin-ichi HAMADA ; Takao KATAOKA ; Je-Tae WOO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1997
卷号：20
期号：9
页码：1017-1019
DOI：10.1248/bpb.20.1017
出版社：The Pharmaceutical Society of Japan
摘要：Gallic acid (GA) and chebulagic acid (CA) were isolated from the extract of a herbal medicine, kashi (myrobalans : the fruit of Terminalia chebula) as active principles that blocked the cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. GA and CA inhibited the killing activity of CD8⁺ CTL clone at IC₅₀ values of 30 μM and 50 μM, respectively. Granule exocytosis in response to anti-CD3 stimulation was also blocked by GA and CA at the equivalent concentrations.
关键词：chebulagic acid;gallic acid;CTL;immunosuppression;tannin;Terminalia chebula