文章基本信息

标题：Apoptotic Cell Death Induced by Physarumin (Hemagglutinin from Myxomycete, Physarum polycephalum)
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作者：Chifumi NUMATA ; Masayoshi YOKOTA ; Masahiro HOSONO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：3
页码：214-218
DOI：10.1248/bpb.21.214
出版社：The Pharmaceutical Society of Japan
摘要：Physarumin, a carbohydrate-binding protein (hemagglutinin or lectin), was isolated from the plasmodium of Physarum polycephalum. Physarumin agglutinated not only several species of erythrocytes but also tumor cells such as AH109A ascites hepatoma cells, sarcoma 180 ascites cells and mouse leukemia P388 cell lines. Physarumin had tumor cell growth -inhibitory activity, and induced the apoptosis of P388 cell lines. Physarumin-induced apoptosis required binding to a 68 kDa counter-receptor on the P388 cell surface. Since the agglutinating and antiproliferative activities of physarumin were inhibited by asialofetuin and thyroglobulin, respectively, it is suggested that physarumin reacts with the galactose moiety of carbohydrate chains of physarumin receptor.
关键词：hemagglutinin;Physarum polycephalum;tumor cell agglutination;antiproliferative effect;apoptosis