文章基本信息

标题：Effects of Codeine on the Agitating Force and Gastrointestinal Transit Time in Dogs, for Use in Drug Absorption Studies
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作者：Noriko KATORI ; Nobuo AOYAGI ; Shigeo KOJIMA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：4
页码：418-420
DOI：10.1248/bpb.21.418
出版社：The Pharmaceutical Society of Japan
摘要：Drug absorption studies using dogs have been difficult because of different gastrointestina(GI) conditions between dogs and humans, including dogs' shorter intestinal transit time and strong agitation force in the GI tract. We attempted to modify the agitation force and GI transit time in dogs using codeine. The agitation force was examined based on the in vitro/in vivo correlation for a CR tablet of acetaminophen showing agitation-dependant release. Codeine improved the GI condition better than atropine or loperamide, employed previously.
关键词：codeine;acetaminophen;drug absorption;hydrohynamic flow;gastrointestinal(GI) transit time;in vitro/in vivo relationship