文章基本信息

标题：Gastric Cytoprotective Activity of Dehydroleucidine in Rats. Role of Prostaglandins
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作者：Alejandra O. M. MARIA ; Ana M. FRANCHI ; Graciela H. WENDEL 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：4
页码：335-338
DOI：10.1248/bpb.21.335
出版社：The Pharmaceutical Society of Japan
摘要：Previously, we reported that dehydroleucodine (DhL), a sesquiterpene lactone, protected the gastric mucosa of rats from absolute ethanol-induced lesions in a dose-dependent fashion. The mechanism is not mediated by an antiacid secretory action and DhL stimulated mucous production. In the present study, we report the effect of DhL on the mucosal production of prostaglandin E (PGE) and the mucosal release of PGE₂ in rats stomach. DhL in acute treatment does not modify these values decreased by previous treatment with indomethacin or absolute ethanol. However, DhL in subchronic treatment significantly enhanced the mucosal production of PGE and the mucosal release of PGE₂. Also, indomethacin pretreatment resulted in a significant reduction of the cytoprotective action of DhL. These results indicate the participation of endogenous prostaglandins in DhL protection against ethanol damage. Moreover, we suggest that the gastric protective activity of DhL against ethanol induced gastric mucosal damage is mediated, at least in part, through PGE and PGE₂ in subchronic treatment.
关键词：prostaglandin E;prostaglandin E2;gastric cytoprotection;dehydroleucodine