文章基本信息

标题：Structure-Activity Relationships of Saponins and Cardiac Glycosides. III. β-L-Xylopyranosyl-(1→6)-α- and -β-D-Glucopyranosides
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作者：Masayuki TAKECHI ; Chikari UNO ; Yasuo TANAKA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：11
页码：1234-1235
DOI：10.1248/bpb.21.1234
出版社：The Pharmaceutical Society of Japan
摘要：Comparisons of the biological activities of diosgenyl, methyl glycyrrhetinate or digitoxigenyl 3-O-β-L-xylopy-ranosyl-(1→6)-β-D-glucopyranoside with those of other previously tested glycosides confirmed our assumption that both the hemolytic and antifungal activities of steroid saponins are generally parallel to each other, while almost all hemolytic triterpenoid saponins and nonhemolytic ones have no antifungal activity, and that cardiac diglycosides having a (1→4) sugar linkage have stronger activities than those with a (1→6) or a (1→2) linkage. On the other hand, the case of the diosgenyl 3-O-β-L-xylopyranosyl-(1→6)-α-D-glucopyranoside didn't conform to the above assumption, but those of methyl glycyrrhetinate and digitoxigenyl did.
关键词：saponin;hemolysis;antifungal activity;cardiac glycoside;anti-ATPase activity;antiviral activity