文章基本信息

标题：Studies of Aloe. VI. Cathartic Effect of Isobarbaloin
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作者：Yasuko ISHII ; Yoshio TAKINO ; Toshimasa TOYO'OKA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1998
卷号：21
期号：11
页码：1226-1227
DOI：10.1248/bpb.21.1226
出版社：The Pharmaceutical Society of Japan
摘要：The cathartic effect of isobarbaloin, a stereoisomer of barbaloin (compound principally responsible for the cathartic activity of Aloe), was examined in male rats by oral administration. Individual differences in sensitivity in the laxative activity of isobarbaloin and barbaloin was not found. The cathartic activity (ED₅₀) of isobarbaloin in barbaloin positive rats was 19.2 mg/kg, nearly equal to that of barbaloin (19.5 mg/kg). Also, isobarbaloin administered orally was demonstrated to decompose to aloe-emodin-9-anthrone (active metabolite of barbaloin) as well as to barbaloin. Therefore, it is considered that the mechanism underlying the cathartic effect of isobarbaloin is the same as that of barbaloin.
关键词：isobarbaloin;Aloe;barbaloin;cathartic effect mechanism;aloe-emodin-9-anthrone