文章基本信息

标题：Synthesis and Preliminary Anticancer Evaluation of 10-Hydroxycamptothecin Analogs
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作者：Pei Yu ; Longfei Xia ; Jing Zhao 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2012
卷号：35
期号：8
页码：1295-1299
DOI：10.1248/bpb.b12-00145
出版社：The Pharmaceutical Society of Japan
摘要：We have synthesized new 10-hydroxycamptothecin (HCPT) analogs and evaluated their anticancer activity in cell culture and in experimental animal tumor model. Although the new analogs were less potent against L1210 leukemia cells in vitro , some of them were more efficacious against L1210 leukemia in vivo compared to the parent HCPT.
关键词：anticancer;10-hydroxycamptothecin;analog