文章基本信息

标题：Novel Acridine-Based N-Acyl-homoserine Lactone Analogs Induce Endoreduplication in the Human Oral Squamous Carcinoma Cell Line SAS
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作者：Hongbo Chai ; Masaharu Hazawa ; Yoichiro Hosokawa 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2012
卷号：35
期号：8
页码：1257-1263
DOI：10.1248/bpb.b12-00033
出版社：The Pharmaceutical Society of Japan
摘要：The cytotoxicity of novel acridine-based N -acyl-homoserine lactone (AHL) analogs was investigated on the human oral squamous carcinoma cell line SAS. One analog induced G2/M phase arrest at 5.3–10.6 µ M and induced polyploidy at a higher dose (21.2 µ M ). Importantly, treatment of SAS cells with a combination of the AHL analog and the Jun N-terminal kinase (JNK) inhibitor, SP600125, prevented mitosis and induced polyploidy. The AHL analog synergized with X -irradiation to inhibit clonogenic survival of SAS cells; however, its radiosensitizing effects were relative to not X -irradiation-induced apoptosis but mitotic failure following enhanced expression of Aurora A and B. These results suggest that the active AHL analog showed growth-suppressive and radiosensitizing effects, which involve polyploidy followed by G2/M accumulation and atypical cell death in the SAS cell line.
关键词：Quorum sensing;N-acyl-homoserine lactone;acridine;SP600125;endoreduplication;oral squamous carcinoma cell