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  • 标题:Antidiabetic Mechanism of Bakumondo-inshi
  • 本地全文:下载
  • 作者:Toshihiro MIURA ; Mami KAKO ; Eriko ISHIHARA
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:1999
  • 卷号:22
  • 期号:4
  • 页码:388-390
  • DOI:10.1248/bpb.22.388
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:To determine the antidiabetic mechanism of Bakumondo-inshi (BI), we examined its effects on glucose absorption, α-glucosidase activity, sodium-dependent glucose transporter and facilitative glucose transporter isoform 5 (GLUT5) in small intestine. The oral administration of BI into KK-Ay mice caused a significant decrease in the glucose absorption in small intestine. The small intestine content of active glucose transporter isoform (SGLUT) protein content from KK-Ay mouse significantly decreased in the BI-treated KK-Ay mice compared to that in the controls. However, the small intestine content of facilitative glucose transporter isoform, GLUT5 protein content did not change. The α-glucosidase activity in small intestine significantly decreased in the BI-treated KK-Ay mice. These results suggest that the antidiabetic effect of BI is derived, at least in part, from a decrease of glucose absorption in small intestine, due to the reduction of SGLUT protein content in total membrane of the small intestine and the reduction of α-glucosidase activity. Because of its therapeutic mechanism BI could be a new category of therapeutic agent for non-insulin dependent diabetic mellitus.
  • 关键词:Bakumondo-inshi;glucose absorption;SGLUT;GLUT5;α-glucosidase;Western blotting
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