文章基本信息

标题：Hot Water Extract of Bark of Nikko Maple (Acer nikoense) Induces Apoptosis in Leukemia Cells
本地全文：下载
作者：Kazuo NITTA ; Yukiko OGAWA ; Fukiko NEGISHI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：4
页码：378-381
DOI：10.1248/bpb.22.378
出版社：The Pharmaceutical Society of Japan
摘要：In screening for antitumor constituents in traditional crude drugs, we used three cultured cell lines : mouse leukemia P388 cells, doxorubicin-resistant P388 cells and leczyme (catalytic lectin)-resistant P388 cells. The hot water extract (HWE) of the bark of Nikko maple (Acer nikoense) showed concentration-dependent inhibitory effects on the growth of these three cell lines. DNA fragmentation and morphological changes, accompanied by condensed and fragmented nuclei, were observed in the leukemina cell lines cultured with HWE of the bark of Nikko maple. Treatment with this HWE increased the expression of sialylated glycoconjuagtes on the apoptotic cells. These results suggest that HWE induces cell death via apoptosis in vitro.
关键词：Bark;Nikko maple;Acer nikoense;antitumor activity;apoptosis;sialylated glycoconjugate