文章基本信息

标题：Cycloprodigiosin Hydrochloride Obtained from Pseudoalteromonas denitrificans Is a Potent Antimalarial Agent
本地全文：下载
作者：Hye-Sook KIM ; Mitsuko HAYASHI ; Yasuharu SHIBATA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：5
页码：532-534
DOI：10.1248/bpb.22.532
出版社：The Pharmaceutical Society of Japan
摘要：Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent.The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.
关键词：cycloprodigiosin;Plasmodium falciparum;malaria parasite;antimalarial drug;Pseudoalteromonas denitrificans;chloroquine