文章基本信息

标题：A Rabbit Model for Evaluation of Chlorpromazine-Induced Orthostatic Hypotension
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作者：Yoshinobu TAKATA ; Junichi KURIHARA ; Shigeto SUZUKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：5
页码：457-462
DOI：10.1248/bpb.22.457
出版社：The Pharmaceutical Society of Japan
摘要：The present study was conducted to develop an experimental model for evaluation of chlorpromazine-induced orthostatic hypotension in rabbits. In addition, the α-adrenoceptor blocking effect of chlorpromazine was investigated in isolated rabbit aorta and saphenous vein in comparison with prazosin. Chlorpromazine (0.1 and 1 mg/kg, i.v.) potentiated significantly a decrease in mean blood pressure at 1 min after the onset of head-up tilt in rebbits anesthetized with urethane alone, urethane+α-chloralose or nitrous oxide alone, but not in conscious and morphine+urethane+α-chloralose-anesthetized rabbits. There was a negative correlation (r=-0.986, p<0.01) between the extent of chlorpromazine-induced orthostatic hypotension and the amplitude of tilt-induced reflex tachycardia before chlorpomazine treatment. Both prazosin and pentolinium elicited orthostatic hypotension under all four anesthetic conditions. The pA₂ value for chlorpromazine to antagonize norepinephrine-induced contraction in aorta was significantly larger than that in saphenous vein, whereas prazosin blocked aortic and venous contractions to a similar extent. These results suggest that a rabbit under an anesthesia which impairs tilt-induced reflex tachycardia may be useful for evaluation of orthostatic hypotension by chlorpromazine.The relatively low potential of chlorpromazine to produce orthostatic hypotension may be partly due to its weak venodilating action.
关键词：chlorpromazine;orthostatic hypotension;rabbit;α-adrenoceptor blocking action