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标题：The Anticonvulsive Effect of Glutathione in Mice
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作者：Kazuho ABE ; Kazuko NAKANISHI ; Hiroshi SAITO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1999
卷号：22
期号：11
页码：1177-1179
DOI：10.1248/bpb.22.1177
出版社：The Pharmaceutical Society of Japan
摘要：To explore the role of glutathione as a neuromodulator, we investigated effects of reduced (GSH) and oxidized glutathione (GSSG) on drug-induced convulsions in mice. Intracerebroventricular administration of GSH or GSSG (10-300 nmol) did not produce convulsions. When GSH was administered prior to subcutaneous administration of pentylenetetrazol (80 mg/kg), it significantly inhibited pentylenetetrazol-induced convulsions. The inhibitory effect of GSH was dose dependent, and mimicked by GSSG. In addition, neither GSH nor GSSG affected convulsions induced by subcutaneous administration of N-methyl-DL-aspartate (400 mg/kg). These findings suggest that glutathione has a specific anticonvulsive effect.
关键词：glutathione;convulsion;pentylenetetrazol;N-methyl-DL-aspartate;mice