文章基本信息

标题：Production of LLU-α Following an Oral Administration of γ-Tocotrienol or γ-Tocopherol to Rats
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作者：Akihiro HATTORI ; Takeshi FUKUSHIMA ; Hiroyuki YOSHIMURA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：11
页码：1395-1397
DOI：10.1248/bpb.23.1395
出版社：The Pharmaceutical Society of Japan
摘要：An oral administration of γ-tocotrienol (γ-T3) or γ-tocopherol (γ-Toc) to male rats caused an increase of the concentration of 2, 7, 8-trimethyl-2-(β-carboxyethyl)-6-hydroxy chroman (LLU-α, γ-CEHC), a natriuretic compound, in plasma with a T_max of 9 h. The configuration at C-2 of LLU-α produced from γ-T3 or γ-Toc was assigned as S-form by an HPLC equipped with a chiral column. These data indicated that LLU-α was produced not only from γ-Toc but also γ-T3, without racemization at C-2 in rats.
关键词：LLU-α(γ-CEHC);γ-tocotrienol;γ-tocopherol;rat plasma;HPLC