文章基本信息

标题：Anti-Androgenic Activity of Substituted Azo- and Azoxy-Benzene Derivatives
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作者：Hiroyasu TAKAHASHI ; Toshiyasu ISHIOKA ; Yukiko KOISO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2000
卷号：23
期号：11
页码：1387-1390
DOI：10.1248/bpb.23.1387
出版社：The Pharmaceutical Society of Japan
摘要：Substituted phenylazo and phenylazoxy compounds were systematically prepared and their anti-androgenic activity was measured in terms of (1) the growth-inhibiting effect on an androgen-dependent cell line, SC-3, and (2) the binding affinity of nuclear androgen receptor. Generally, azo/azoxy compounds showed cell toxicity, and the growth-inhibiting effects on SC-3 cells correlated with the toxicity. However, some compounds, including 4, 4'-dinitroazobenzene (25), 4, 4'-dimethoxyazobenzene (33), and 2, 2'-dichloroazoxybenzene (47), possessed potent anti-androgenic activity without apparent cell toxicity.
关键词：anti-androgen;azobenzene;azoxybenzene;androgen receptor;structure-activity relationship